Solid lipid microparticles slm are microscale drug carriers possessing a matrix made from fatty acid, glyceride, fatty alcohol, and solid wax with high melting points. Solid lipid microparticles of controlled release candesartan cilexetil. Formulation and evaluation of controlled release solid lipid. If the inline pdf is not rendering correctly, you can download the pdf file here. Solid lipid nanoparticles slns serve as an alternative carrier system for traditional colloidal carriers like polymeric microparticles, nanoparticles, liposomes and emulsions.
They combine many advantages of drug carrier systems. Typical particle sizes attained are in the range 50100 microns. Formulation and evaluation of chitosan solid lipid. The system consists of spherical solid lipid particles in the nanometer ranges, which are dispersed in water or in aqueous surfactant solution. The aim of this work is to use slms to impart a sustained release profile to a model drug, salbutamol acetonide sa. The carotenoid was added to the lipids after melting to minimize the.
A pluronicfunctionalized silicalipid hybrid pluslh microparticle system for the oral delivery of poorly watersoluble, weak base drugs is reported for the first time. The temperature should be regulated effectively to ensure the solid state of the. Nov 12, 2009 the aerosol performance solid lipid nanoparticles made from compritol stabilized with. In this study, we used a microfluidic technique to encapsulate thermally hydrocarbonized porous silicon thcpsi microparticles within solid lipid microparticles slms to overcome the drawbacks accompanied by thcpsi. Depending upon the method of preparation, microparticles,microspheres or microcapsules can be obtained. To formulate solid lipid microparticles slm of loratadine lrt for the treatment of allergic reactions via the nasal route. Solid lipid microparticles as a sustained release system for.
Solid lipid nanoparticles authorstream presentation. The preparation of solid lipid nanoparticles slns suffers from the drawback of poor incorporation of. Emulsions can be used as precursors for solid lipid particles preparation since lipids, that are solid at room temperature, can be heated 510 c above their melting point to obtain a liquid lipid that can be emulsified with water at the same temperature. Specific objectives were to develop hollow solid lipid micro and nanoparticles using scco 2 technology, and to load the hollow solid lipid micro and nanoparticles with essential oil to develop food grade freeflowing powder. Preparation and in vivo toxicity study of solid lipid microparticles as. Hot ow nanoemulsion solid lipid nanoparticles disadvantages. Preparation of solid lipid microparticles and thcpsi. The slns are dispersed in a chilled emulsifier solution.
The influence of independent variables studied were lipid, surfactant and cosurfactant concentration, volume of aqueous phase, magnetic stirring rate, probe sonicator duration, volume of beaker used and volume of cold aqueous phase. Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. In vitro dissolution test for this study, gelatin capsules containing solid dis. Preparation of acacia tannin loaded lipid microparticles by solid inoilinwater and melt dispersion methods, their characterization and evaluation of their effect on ruminal gas production in vitro. Preliminary studies on solid lipid microparticles of. Formation of solid lipid microparticles from fully. Sustained release biodegradable solid lipid microparticles sciendo. Supercritical fluid technology for development of solid lipid. Experimental design for the optimization of nanoscale solid. Effect of polymeric release modulators on drug release from solid lipid microparticles by asma abdelraouf khaled fakhoury supervisor dr. Mohammad khalil this thesis was submitted in partial fulfillment of the requirements for the master degree in pharmaceutical sciences faculty of graduate studies. Apr 28, 2016 premix using a stirrer to form a coarse preemulsion high pressure homogenization at a temperature above the lipid m. Formation of bioactivecarrier hollow solid lipid micro and.
Techniques for the preparation of solid lipid nano and microparticles chapter pdf available august 2015 with 2,230 reads how we measure reads. Due to their solid matrix, solid lipid nanoparticles can protect the. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of bioactive compounds and their transfer to the site of. Solid lipid microparticles slm are microscale drug carriers possessing matrix made from fatty acid, glyceride, fatty alcohol, and solid wax with high melting points 3. Jan 01, 2008 read solid lipid microparticles containing watersoluble compounds of different molecular mass. A simple and green process based on supercritical carbon dioxide scco 2 technology was used to produce solid lipid microparticles from fully hydrogenated canola oil fhco. Drugexcipient compatibility and crystallinity characteristics of microparticles were investigated by fourier transform infrared. Twenty individually weighed units of capsules containing solid dispersions or lipid microparticles were taken at random and the average mass was determined. Pluronicfunctionalized silicalipid hybrid microparticles. Absorption study of genistein using solid lipid microparticles and. Production, characterisation and release profiles, food research international on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The aim of this work was to develop dry powder inhaler dpi. This article is from daru journal of pharmaceutical sciences, volume 22. Preparation of acacia tannin loaded lipid microparticles by solid inoilinwater and melt dispersion methods, their characterization and evaluation of their effect on ruminal gas production in vitro festus a.
In this study, the effect of particle size of genisteinloaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability. Azithromycinloaded respirable microparticles for targeted pulmonary delivery for the treatment of pneumonia qiyue wang a, gujie mi b, daniel hickey b, yanan li a, jiasheng tu a. It is identical to an oilinwater emulsion for parenteral nutrition but the liquid lipid oil of the emulsion has been replaced by a solid lipid, i. Slns act as a new colloidal drug carrier for intravenous applications.
Solid lipid nanoparticles sln and microparticles slmhave been pictured as a very interesting platforms on development of formulations for biomedical applications. Microfluidic templated mesoporous siliconsolid lipid. Microemulsion based method slns can be produced by microemulsification of molten lipids, as the internal phase and subsequent dispersion of the microemulsion in aqueous medium under mechanical stirring. The solid lipid microparticles slm were prepared by the micro. The emulsifier used depends on administration routes and is more limited for. In general, the lipid matrix was dissolved in the organic solvents and served as the inner oil. The lipid phase 4 or 6% ww solid lipid was fully melted by heating and the. There are different techniques for the preparation of solid lipid nanoand microparticles. Chilled processing further facilitated particle milling by increasing the lipid fragility.
Polymer lipid microparticles for pulmonary delivery. The lipid core is stabilized by surfactants emulsifiers. The solid lipid nanoparticles sln of chitosancbz were prepared. The amount of drug encapsulated can vary up to 95% for. Jun, 2012 the present work aims at preparing aqueous suspension of solid lipid nanoparticles containing chitosan ct which is a biopolymer that exhibits a number of interesting properties which include controlled drug delivery. Solid lipid budesonide microparticles for controlled release. The introduction part of this research article first details the potential advantages of solid lipid microparticles slms as drug carrier compared to liposomes and polymeric microspheres. Sln are nanoparticles made of solid lipids with a photon correlation spectroscopy pcs mean diameter approximately between 50 and nm 1. The prepared lipid microparticles are then dispersed in a cold emulsifier solution at or below room temperature. Encapsulation of betacarotene in solid lipid microparticles.
Preparation of acacia tannin loaded lipid microparticles by. Solid lipid nanoparticles a promising drug delivery system. A major challenge for a drugdelivery system is to engineer stable drug carriers with excellent biocompatibility, monodisperse size, and controllable release profiles. The drug is dissolved,entrapped, encapsulated or attached to a microparticle matrix. Carbamezapine cbz is a lipophilic drug which shows it antiepileptic activity by inactivating sodium channels. Comparative study of sustainedrelease lipid microparticles.
The effects of pressure 122, 211 and 300 bar and nozzle diameter 0. Although, compritol 888 ato has acceptable regulatory and safety profiles and although the number of articles that emphasize on its applicabil. A solid lipid nanoparticle is typically spherical with an average diameter between 10 and nanometers. Solid lipid nanoparticles and nanostructured lipid carriers. Pdf techniques for the preparation of solid lipid nano. Techniques for the preparation of solid lipid nano and microparticles.
The purpose of this research was to investigate the effects of processing conditions on the characteristics of solid lipid microparticles slm with a pote. To formulate solidified reverse micellar solutions srmsbased solid lipid microparticles. A highly effective pluslh microparticle system was composed of labrasol as the lipid phase, pluronic f127 as the polymeric precipitation inhibitor ppi, and silica nanoparticles as the solid carrier. In effect, the drug containing solid lipid is pulverized to micropaticles by ballmortar milling. Sep 19, 2015 lipid nanoparticles lnps have attracted special interest during last few decades. Solid lipid nanoparticles are one of the novel potential colloidal carrier systems as alternative materials to polymers which is identical to oil in water emulsion for parenteral nutrition, but the liquid lipid of the emulsion has been replaced by a solid lipid shown on fig. Techniques for the preparation of solid lipid nano and.
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